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Liquid Nitrogen for Molluscum Contagiosum: Does It Work?

Molluscum contagiosum is a viral skin infection caused by the molluscum contagiosum virus (MCV). It is characterized by small, painless bumps that can appear anywhere on the body. While molluscum contagiosum is generally harmless, it can be a source of discomfort and embarrassment, prompting many to seek treatment. One common treatment option is cryotherapy, which involves using very cold liquid nitrogen to freeze and destroy the lesions. In this blog, we will look at the effectiveness of liquid nitrogen for molluscum contagiosum treatment, its potential benefits, and also the risks associated with it.

What is Cryotherapy?

Cryotherapy is a medical treatment that uses extreme colds to destroy abnormal tissues. In the case of molluscum contagiosum treatment, liquid nitrogen, the second coldest substance on earth, is used. Liquid nitrogen can have a temperature as low as -320 degrees Fahrenheit, making it effective in freezing and destroying the virus-infected cells.

How is Cryotherapy Performed?

During cryotherapy for molluscum contagiosum, a healthcare provider applies liquid nitrogen directly to each lesion. This can be done using a cotton-tipped swab dipped in liquid nitrogen or a specialized applicator. Each lesion is treated for about 6 to 10 seconds. The extreme cold freezes the cells, causing them to die and eventually fall off.

Effectiveness of Cryotherapy

Cryotherapy has been shown to be a rapidly effective treatment for molluscum contagiosum. In a randomized trial, it was demonstrated that cryotherapy could quickly reduce the number of lesions. This is particularly beneficial for individuals who have numerous lesions or those who want a quick resolution.

Tolerability of Cryotherapy

The treatment is generally well tolerated by adolescents and adults. However, the pain associated with cryotherapy can limit its use in young children. The application of the freezing liquid nitrogen can be painful, and this pain may be distressing for young children, especially if they have multiple lesions that need treatment. The cold sensation and subsequent discomfort can be emotionally traumatic for some children.

Potential Side Effects of Cryotherapy

While cryotherapy can be effective, it also has potential side effects. Some of the common side effects include:

  • Pain and Discomfort: The treatment can inflict pain, especially for young children.

  • Scarring: There is a risk of scarring after the lesions fall off.

  • Hypopigmentation: This is a condition where the skin becomes lighter in the treated Area. This can be more prominent in individuals with darker skin tones.

  • Hyperpigmentation: In some cases, the skin may become darker instead of lighter.

It's important to consider these potential side effects before opting for cryotherapy. The pros and cons should be carefully considered, especially for patients with darker skin, who may be more prone to hypopigmentation.

Alternatives to Cryotherapy

If cryotherapy seems too painful or risky, there are alternative treatments available for molluscum contagiosum. These include:

  • Topical Treatments: Various creams and ointments can be applied to the lesions. These treatments may take longer to show results but are less painful than cryotherapy.

  • Curettage: This involves scraping off the lesions with a sharp instrument. It is usually done under local anesthesia to minimize pain.

  • Laser Therapy: Lasers therapy is being used to destroy the lesions. This method is less commonly used but can be effective.

  • Oral Medications: In some cases, oral antiviral medications may be prescribed.

Considering the Best Treatment Option

When deciding on the best treatment for molluscum contagiosum, it's important to consider various factors, including the number of lesions, their location, the patient's age, and their skin type. Consulting with a healthcare provider is very important to determine the best treatment method.

Cryotherapy for Different Age Groups

Cryotherapy may not be suitable for all age groups. Here’s a closer look at how different age groups may respond to the treatment:

  • Young Children: As mentioned earlier, cryotherapy can be painful and emotionally traumatic for young children. If the child has only a few lesions, it might be better to wait and see if the lesions go away on their own, as they often do.

  • Adolescents: Teenagers may tolerate cryotherapy better than younger children. However, the potential for scarring and pigmentation changes should be considered.

  • Adults: Adults generally tolerate cryotherapy well, making it a viable option for molluscum contagiosum treatment.

What to Expect During and After Treatment

During cryotherapy, you may feel a cold sensation and some pain at the site of application. After the treatment, the treated Area may become red and swollen. Blisters may form, which is a normal reaction. The lesions will eventually fall off, usually within a few weeks.

Aftercare Tips

To ensure proper healing after cryotherapy, follow these tips:

  • Keep the Area Clean: Gently wash the treated Area with soap and water.

  • Avoid Scratching: Scratching can increase the risk of infection and scarring.

  • Moisturize: Apply a gentle moisturizer to prevent dryness and promote healing.

  • Sun Protection: Protect the area from direct sun exposure to prevent pigmentation changes.


Cryotherapy using freezing liquid nitrogen can be an effective treatment for molluscum contagiosum, providing a quick resolution to the lesions. However, the potential for pain, scarring, and pigmentation changes should be carefully considered, especially in young children and individuals with darker skin tones. Alternatives to cryotherapy, such as topical treatments and laser therapy, may be less painful options but could take longer to show results. Consulting with a dermitologist is essential to determine the most suitable treatment for each individual case.

By understanding the pros and cons of cryotherapy and exploring alternative treatment options, patients and caregivers can make educated decisions about the best way to manage molluscum contagiosum. This approach ensures that the treatment mathces with the patient's needs and minimizes the risk of adverse effects, leading to better overall outcomes.


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